Antidepressant. Brand name: [[wellbutrin]] Amfebutamone Hydrochloride, earlier name.

topic:: [[anti-depressant]]

Mechanism of Action

Replace inhibition of norepinephrine and dopamine. May also cause presynaptic release of norepinephrine and dopamine. Human research indicates modest effects on dopamine. https://psychopharmacologyinstitute.com/section/the-psychopharmacology-of-bupropion-an-illustrated-overview-2051-4056

Side Effects

Short Term Memory

I've read anecdotal accounts of memory impairment after long term use.

Seizure

Dosage above 450mg/day increase the risk of seizure exponentially. https://psychopharmacologyinstitute.com/section/the-psychopharmacology-of-bupropion-an-illustrated-overview-2051-4056

The lowest dose which has been associated with seizure is 575 mg.(19857406) With overdoses over ~3 grams, seizures become increasingly likely.(Rusnyak 2018, 19857406) https://emcrit.org/ibcc/bupropion/

Abuse Potential of Bupropion

https://journals.lww.com/journaladdictionmedicine/fulltext/2015/03000/possible_addiction_transference_from_cocaine.13.aspx

a uniquely dangerous and increasingly common source of intoxication https://emcrit.org/ibcc/bupropion/

• Bupropion is far more dangerous than other commonly used antidepressants (especially selective serotonin-release inhibitors).  In particular, bupropion's ability to cause cardiogenic shock is somewhat unique.
• Tricyclic antidepressants have largely fallen out of favor for treatment of depression, but bupropion remains commonly used.  This makes bupropion one of the most dangerous antidepressants in widespread circulation.(28944696)
• The extended-release formulation of bupropion may cause delayed emergence of symptoms (a delayed “toxin bomb”).  Subsequently, ongoing drug absorption can be relentless.
• https://emcrit.org/ibcc/bupropion/

Pharmacokinetics

Reddit where q about how to modify metabolism of bupropion to get mainly [[DAT]] action and less [[NET]]

[[CYP2B6]]

Bupropion and its three main metabolites (hydroxybupropion, threohydrobupropion, and erythrohydrobupropion) have significant centra noradrenergic activity at clinically relevant doses. https://psychscenehub.com/psychinsights/bupropion-mechanism-of-action-psychopharmacology-clinical-application/

Other

https://toxandhound.com/toxhound/illbutrin/ Calls wellbutrin a "a sustained release bath salt", for being a Catherine, like for example methadone.